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The proportion of lean mass loss observed with GLP-1 medications appears similar to that seen with other weight loss interventions, including dietary restriction alone and bariatric surgery

Featured Authors Craig Nunemaker, PhD Ohio University Ian Neeland, MD Case Western Reserve University Kathleen Dungan, MD, MPH The Ohio State University

The gastrointestinal effects of GLP-1 agonists may theoretically affect levothyroxine absorption, though clinical evidence for this interaction is limited

GI side effects during escalation vs maintenance Both compounds share an important characteristic: most gastrointestinal side effects occur during dose escalation, not during maintenance

Therefore, partnering with a healthcare provider ensures tailored advice for optimal results